A practical green approach to diversified spirochromene/spiropyran scaffolds via a glucose–water synergy driven organocatalytic system†
Abstract
The development of a versatile, new biomimetic glucose–water organocatalytic system promoted, one-pot green and practical method for the synthesis of diversified spirochromenes/spiropyrans is reported. To the best of our knowledge this is the first report on the use of a glucose–water system as a catalyst in organic synthesis. Superior green credentials, operational simplicity, easy scale up and recyclability of the catalyst are the key strengths of this method, which combined with attributes like broad substrate scope, mild reaction conditions, short reaction times, cost effectiveness, high atom economy and good to excellent yields make the present method a distinct improvement over existing methods.