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Issue 20, 2018
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One-step highly selective borylation/Suzuki cross-coupling of two distinct aryl bromides in pure water

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Abstract

A Na2PdCl4-catalysed B2(OH)4-mediated direct cross-coupling of two distinct aryl bromides in pure water is described. This one-step borylation/Suzuki method exhibits an outstanding cross-coupling selectivity and no tendency to produce homocoupling products, therefore leading to biaryls and heterobiaryls in moderate to good yields. Moreover, the reaction has high regio-selectivity and can be scaled-up. Using such a simple, economical and practical protocol, the unsymmetrical diarylation of 3,5-dibromopryidine is achieved.

Graphical abstract: One-step highly selective borylation/Suzuki cross-coupling of two distinct aryl bromides in pure water

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Publication details

The article was received on 04 May 2018, accepted on 17 Sep 2018 and first published on 18 Sep 2018


Article type: Letter
DOI: 10.1039/C8NJ02184H
Citation: New J. Chem., 2018,42, 16464-16468
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    One-step highly selective borylation/Suzuki cross-coupling of two distinct aryl bromides in pure water

    S. D. Xu, F. Z. Sun, W. H. Deng, H. Hao and X. H. Duan, New J. Chem., 2018, 42, 16464
    DOI: 10.1039/C8NJ02184H

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