Smart electrochemical sensing platform for the simultaneous determination of psychotic disorder drugs isopropamide iodide and trifluoperazine hydrochloride

Abstract

A novel, simple and highly sensitive sensor for the simultaneous determination of isopropamide iodide (ISP) and trifluoperazine hydrochloride (TFP) was developed. A carbon paste electrode was modified with m-cresol purple (MCP) and carboxylated multiwalled carbon nanotubes (MWCNTs). Different techniques were used to characterize the nanostructure and performance of the sensor. Under the optimized experimental conditions, ISP and TFP showed linear responses over the ranges of 5.50 × 10⁻⁶–1.70 × 10⁻⁴ and 5.00 × 10⁻⁷–1.34 × 10⁻³ mol L⁻¹, respectively. The detection limits for ISP and TFP were found to be 9.91 × 10⁻⁷ mol L⁻¹ and 1.10 × 10⁻⁷ mol L⁻¹, respectively. Satisfactory recoveries of analytes from these samples were demonstrated, indicating that the suggested sensor is highly suitable for clinical analysis, quality control and routine determination of ISP and TFP in pharmaceutical formulations and human fluids.