Issue 12, 2018

UV365 light promoted catalyst-free synthesis of pyrimido[4,5-b]quinoline-2,4-diones in aqueous-glycerol medium

Abstract

Herein, a highly efficient and environmentally benign protocol for the synthesis of biologically important pyrimido[4,5-b]quinolinone-2,4-diones from aromatic amines, barbituric acid and aryl aldehyde is reported. This process takes place at room temperature under direct irradiation from a UV365 light source in the absence of a photocatalyst. The reported approach has several advantages such as high yield, clean reaction conditions, chromatography-free synthesis and the use of a cheap water–glycerol solvent system, which is also an environmentally friendly solvent. The applicability of this protocol for the large-scale synthesis of pyrimido[4,5-b]quinolinone-2,4-diones without wasting any expensive chemicals is an added advantage.

Graphical abstract: UV365 light promoted catalyst-free synthesis of pyrimido[4,5-b]quinoline-2,4-diones in aqueous-glycerol medium

Supplementary files

Article information

Article type
Paper
Submitted
25 Mar 2018
Accepted
19 Apr 2018
First published
19 Apr 2018

New J. Chem., 2018,42, 9436-9442

UV365 light promoted catalyst-free synthesis of pyrimido[4,5-b]quinoline-2,4-diones in aqueous-glycerol medium

G. S. Nongthombam, G. K. Kharmawlong, J. E. Kumar and R. Nongkhlaw, New J. Chem., 2018, 42, 9436 DOI: 10.1039/C8NJ01459K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements