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Issue 15, 2018
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Synthesis, photophysical, antibacterial and larvicidal studies on triazolophanes with 5-nitro isophthalate functionality at the intraannular position

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Abstract

1 : 1 and 2 : 2 oligomeric triazolophanes with 5-nitro isophthalate and triazolyl functionalities at the intraannular position have been synthesized by copper(I) catalyzed 1,3 dipolar cycloaddition of the corresponding propargylic esters with various phenyl substituted aliphatic azides under mild conditions through click methodology. The 1 : 1 oligomeric triazolophanes exhibit good target binding ability and better antibacterial activity against Staphylococcus aureus, Bacillus subtilis, Salmonella typhi and Escherichia coli bacteria than the 2 : 2 oligomeric triazolophanes, supported by molecular docking studies, and triazolophanes T3, T4 and T5 show good larvicidal activity.

Graphical abstract: Synthesis, photophysical, antibacterial and larvicidal studies on triazolophanes with 5-nitro isophthalate functionality at the intraannular position

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Publication details

The article was received on 13 Mar 2018, accepted on 19 Jun 2018 and first published on 29 Jun 2018


Article type: Paper
DOI: 10.1039/C8NJ01248B
New J. Chem., 2018,42, 12684-12691

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    Synthesis, photophysical, antibacterial and larvicidal studies on triazolophanes with 5-nitro isophthalate functionality at the intraannular position

    S. Selvarani, P. Rajakumar, S. Nagaraj, M. Choudhury and D. Velmurugan, New J. Chem., 2018, 42, 12684
    DOI: 10.1039/C8NJ01248B

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