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Issue 12, 2018
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Incorporation of Fmoc-Y nanofibers into Ca-alginate hydrogels for improving their mechanical properties and the controlled release of small molecules

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Abstract

The simple peptide Fmoc-tyrosine (Fmoc-Y) with a self-assembled nanofiber structure was incorporated into Ca-alginate hydrogels to create an interpenetrating network (IPN) hybrid hydrogel. SEM and CD analysis was employed to confirm the integrity of the Fmoc-Y nanofiber structure. In the IPN hybrid hydrogel, the self-assembled Fmoc-Y nanofiber hydrogel can reinforce the Ca-alginate network. The IPN hydrogel exhibits enhanced storage moduli and fracture energy, about several times compared to those of Ca-alginate, Fmoc-Y and semi-IPN hydrogels. Furthermore, the IPN hydrogel reveals minimal release (less than 1%) for hydrophilic small molecules at acidic pH and sustained release at physiological pH, which can be achieved by simply tuning the Fmoc-Y concentration. Owing to the cost-efficiency of the raw materials and ease of fabrication, the synthesized hybrid hydrogels provide new options for diverse applications.

Graphical abstract: Incorporation of Fmoc-Y nanofibers into Ca-alginate hydrogels for improving their mechanical properties and the controlled release of small molecules

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Publication details

The article was received on 12 Feb 2018, accepted on 24 Apr 2018 and first published on 25 Apr 2018


Article type: Paper
DOI: 10.1039/C8NJ00729B
Citation: New J. Chem., 2018,42, 9651-9657
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    Incorporation of Fmoc-Y nanofibers into Ca-alginate hydrogels for improving their mechanical properties and the controlled release of small molecules

    J. Chen, N. Tao, S. Fang, Z. Chen, L. Liang, X. Sun, J. Li and Y. Liu, New J. Chem., 2018, 42, 9651
    DOI: 10.1039/C8NJ00729B

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