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Issue 14, 2018
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Enantiomeric separation and simulation study of eight anticholinergic drugs on an immobilized polysaccharide-based chiral stationary phase by HPLC

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Abstract

The enantiomeric separation of eight anticholinergic drugs was first systematically examined on a derivative polysaccharide chiral stationary phase (CSP), i.e. Chiralpak ID in the normal phase mode. Except for scopolamine hydrobromide and benzhexol hydrochloride, the other six analytes including atropine sulfate, phencynonate, dipivefrine hydrochloride, tropicamide, homatropine methylbromide and oxybutynin were either completely or partially separated under the optimized mobile phase conditions with resolutions of 3.98, 2.52, 2.02, 2.14, 1.80 and 0.41, respectively. The influences of organic modifier types and content, and base/acid additives on enantiomeric separation were evaluated and optimized. Furthermore, a simulation study was also used to explain the chiral recognition mechanisms of this class of drug enantiomers on Chiralpak ID for the first time. The modeling data were in agreement with the chromatographic results concerning enantioselectivity.

Graphical abstract: Enantiomeric separation and simulation study of eight anticholinergic drugs on an immobilized polysaccharide-based chiral stationary phase by HPLC

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Article information


Submitted
08 Feb 2018
Accepted
04 Jun 2018
First published
06 Jun 2018

New J. Chem., 2018,42, 11724-11731
Article type
Paper

Enantiomeric separation and simulation study of eight anticholinergic drugs on an immobilized polysaccharide-based chiral stationary phase by HPLC

M. Li, B. Zhang, J. Yu, J. Wang and X. Guo, New J. Chem., 2018, 42, 11724
DOI: 10.1039/C8NJ00685G

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