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Synthesis and preliminary evaluation of the anti-cancer activity on A549 lung cancer cells of a series of unsaturated disulfides

Abstract

We synthesized a series of unsaturated disulfides and we performed a preliminary anticancer test on A549 lung cancer cells. The natural molecule diallyl disulfide is the lead compound in this study. We synthesized five analogues, two of which exhibited a promising anti-tumor activity in vitro.

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Publication details

The article was received on 04 Oct 2018, accepted on 01 Dec 2018 and first published on 05 Dec 2018


Article type: Research Article
DOI: 10.1039/C8MD00503F
Citation: Med. Chem. Commun., 2018, Accepted Manuscript
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    Synthesis and preliminary evaluation of the anti-cancer activity on A549 lung cancer cells of a series of unsaturated disulfides

    F. Olivito, N. Amodio, M. L. Di Gioia, M. Nardi, O. Manuela, G. Juli, P. Tassone and A. Procopio, Med. Chem. Commun., 2018, Accepted Manuscript , DOI: 10.1039/C8MD00503F

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