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Issue 10, 2018
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Medicinal chemistry of acridine and its analogues

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‘Acridine’ along with its functional analogue ‘Acridone’ is the most privileged pharmacophore in medicinal chemistry with diverse applications ranging from DNA intercalators, endonuclease mimics, ratiometric selective ion sensors, and P-glycoprotein inhibitors in countering the multi-drug resistance, enzyme inhibitors, and reversals of neurodegenerative disorders. Their interaction with DNA and ability of selectively identifying numerous biologically useful ions has cemented exploitability of the acridone nucleus in modern day therapeutics. Additionally, most derivatives and salts of acridine are planar, crystalline, and stable displaying a strong fluorescence which, when coupled with their marked bio selectivity and low cytotoxicity, enables the studying and monitoring of several biochemical, metabolic, and pharmacological processes. In this review, a detailed picture covering the important therapeutic aspects of the acridone nucleus and its functional analogues is discussed.

Graphical abstract: Medicinal chemistry of acridine and its analogues

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The article was received on 04 Aug 2018, accepted on 14 Aug 2018 and first published on 14 Aug 2018

Article type: Review Article
DOI: 10.1039/C8MD00384J
Med. Chem. Commun., 2018,9, 1589-1618

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    Medicinal chemistry of acridine and its analogues

    P. Prasher and M. Sharma, Med. Chem. Commun., 2018, 9, 1589
    DOI: 10.1039/C8MD00384J

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