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Screening of the Pathogen Box reveals new starting points for anti-trypanosomal drug discovery

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Abstract

This study aimed to uncover new starting points for anti-trypansomal drug discovery through the screening of the Pathogen Box against Trypanosoma brucei brucei. Our study identified compounds 35, 39, 46, 53 and 56 whose activity and selectivity highlighted them as promising candidates with potential for further study and optimisation.

Graphical abstract: Screening of the Pathogen Box reveals new starting points for anti-trypanosomal drug discovery

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Publication details

The article was received on 27 Jun 2018, accepted on 30 Sep 2018 and first published on 26 Oct 2018


Article type: Research Article
DOI: 10.1039/C8MD00319J
Citation: Med. Chem. Commun., 2018, Advance Article
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    Screening of the Pathogen Box reveals new starting points for anti-trypanosomal drug discovery

    C. G. L. Veale and H. C. Hoppe, Med. Chem. Commun., 2018, Advance Article , DOI: 10.1039/C8MD00319J

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