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Issue 6, 2018
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Antitumor effects of melanin from Lachnum YM226 and its derivative in H22 tumor-bearing mice

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Abstract

In the present study, we investigated the anti-tumor activities of the intracellular homogeneous melanin (LM) of Lachnum YM226 and its derivative (ALM) on liver cancer using murine H22 hepatocarcinoma model. The results showed that LM and ALM (50 and 200 mg kg−1) could effectively inhibit tumor growth of H22 tumour-bearing mice. The body weight, liver, spleen and thymus indices also improved in the LM and ALM treated groups. Moreover, the levels of alanine aminotransferase (ALT), aspartate aminotransaminase (AST), alkaline phosphatase (ALP), creatinine (CRE), blood urea nitrogen (BUN) and uric acid (UA) were lowered. Serum cytokines of interleukin-2 (IL-2), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) were increased on LM and ALM administration, while LM and ALM significantly decreased the vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) levels. The H&E staining indicated that LM and ALM exhibited antitumor activity in vivo by promoting apoptosis and inhibiting angiogenesis. The anti-tumor effect of ALM was more significant than that of LM for the same dose. In summary, the findings demonstrated that LM and ALM might be promising candidates for the prevention and treatment of HCC.

Graphical abstract: Antitumor effects of melanin from Lachnum YM226 and its derivative in H22 tumor-bearing mice

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Publication details

The article was received on 20 Jan 2018, accepted on 08 May 2018 and first published on 16 May 2018


Article type: Research Article
DOI: 10.1039/C8MD00035B
Citation: Med. Chem. Commun., 2018,9, 1059-1068
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    Antitumor effects of melanin from Lachnum YM226 and its derivative in H22 tumor-bearing mice

    F. Shi, J. Li, Z. Ye, L. Yang, T. Chen, X. Chen and M. Ye, Med. Chem. Commun., 2018, 9, 1059
    DOI: 10.1039/C8MD00035B

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