Issue 8, 2018

Ammonium [11C]thiocyanate: revised preparation and reactivity studies of a versatile nucleophile for carbon-11 radiolabelling

Abstract

Herein we report the preparation of ammonium [11C]thiocyanate via the reaction of [11C]CS2 with ammonia. The [11C]SCN ion is demonstrated as a potent nucleophile that can be used to readily generate a range of 11C-labelled thiocyanate molecules in high conversions. Furthermore, novel 11C-labelled thiazolone molecules can be easily prepared from the intermediate α-thiocyanatophenones via an acid mediated cyclisation reaction.

Graphical abstract: Ammonium [11C]thiocyanate: revised preparation and reactivity studies of a versatile nucleophile for carbon-11 radiolabelling

Supplementary files

Article information

Article type
Research Article
Submitted
18 Aug 2017
Accepted
11 May 2018
First published
02 Jul 2018
This article is Open Access
Creative Commons BY license

Med. Chem. Commun., 2018,9, 1311-1314

Ammonium [11C]thiocyanate: revised preparation and reactivity studies of a versatile nucleophile for carbon-11 radiolabelling

T. Haywood, S. Cesarec, S. Kealey, C. Plisson and P. W. Miller, Med. Chem. Commun., 2018, 9, 1311 DOI: 10.1039/C7MD00425G

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