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On-chip photodynamic therapy – monitoring cell metabolism using electrochemical microsensors

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Abstract

We introduce a new system which combines metabolic monitoring using electrochemical microsensors with photodynamic therapy on-chip for the first time. Oxygen consumption of T-47D breast cancer cells was measured during therapy with protoporphyrin IX. We determined the efficacy of the therapy and revealed its recovery effects, which underlines the high relevance of continuous monitoring.

Graphical abstract: On-chip photodynamic therapy – monitoring cell metabolism using electrochemical microsensors

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Publication details

The article was received on 02 Aug 2018, accepted on 29 Sep 2018 and first published on 02 Oct 2018


Article type: Communication
DOI: 10.1039/C8LC00799C
Citation: Lab Chip, 2018, Advance Article
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    On-chip photodynamic therapy – monitoring cell metabolism using electrochemical microsensors

    J. Marzioch, J. Kieninger, A. Weltin, H. Flamm, K. Aravindalochanan, J. A. Sandvik, E. O. Pettersen, Q. Peng and G. A. Urban, Lab Chip, 2018, Advance Article , DOI: 10.1039/C8LC00799C

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