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Issue 24, 2018
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High-yield paper-based quantitative blood separation system

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Abstract

Interest in developing paper-based devices for point-of-care diagnostics in resource-limited settings has risen remarkably in recent decades. In this paper, we demonstrate what we refer to as “high yield passive rrythrocyte removal” (HYPER) technology, which utilizes capillary forces in a unique cross-flow filtration for the separation of whole blood with performance comparable to centrifuges. As we will demonstrate, state-of-the-art passive blood separation methods implemented in paper-based systems exhibit rapid blood cell clogging on the filtration media or serum outlet and yield only about 10–30% of the total serum present in the sample. Our innovation results from the inclusion of a differentiation pad, which exploits hydrodynamic effects to reduce the formation of a fouling layer on the blood filtration membrane resulting in more than 60% serum yield with undiluted whole blood as direct input. To demonstrate the effectiveness of the HYPER technology we implement it in a lateral flow system and demonstrate the accurate quantification of vitamin A and iron levels in whole blood samples in 15 minutes.

Graphical abstract: High-yield paper-based quantitative blood separation system

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Publication details

The article was received on 09 Jul 2018, accepted on 03 Nov 2018 and first published on 13 Nov 2018


Article type: Paper
DOI: 10.1039/C8LC00717A
Citation: Lab Chip, 2018,18, 3865-3871
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    High-yield paper-based quantitative blood separation system

    Z. Lu, E. Rey, S. Vemulapati, B. Srinivasan, S. Mehta and D. Erickson, Lab Chip, 2018, 18, 3865
    DOI: 10.1039/C8LC00717A

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