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Biomolecular recognition on nanowire surfaces modified by the self-assembled monolayer

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Abstract

Molecular recognition is one of the key factors in designing biosensors due to which nanowires functionalized with molecular recognition have attracted a lot of attention as promising candidates for nanostructures embedded in biosensors. However, the difficulty in real-world applications with analytical specificity is that molecular recognition on nanowires mainly depends on antibody modification with multistep modification procedures. Furthermore, the antibody modification suffers from nonspecific adsorption of undesired proteins in body fluid on the nanowires, which causes false responses and lowers sensitivity. Herein, we propose biomolecular recognition using surface-modified nanowires via thiolated 2-methacryloxyethyl phosphorylcholine (MPC-SH). MPC-SH enables self-assembled monolayer (SAM) modification, which contributes to the reduction of nonspecific adsorption of biomolecules onto the nanowires, and the specific capture of a target protein is attained in the presence of calcium ions. Our concept demonstrates the recognition of the biomarker protein on nanowire surfaces modified by MPC-SH SAM with a single step modification procedure.

Graphical abstract: Biomolecular recognition on nanowire surfaces modified by the self-assembled monolayer

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Publication details

The article was received on 27 Apr 2018, accepted on 16 Jul 2018 and first published on 28 Sep 2018


Article type: Communication
DOI: 10.1039/C8LC00438B
Citation: Lab Chip, 2018, Advance Article
  • Open access: Creative Commons BY-NC license
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    Biomolecular recognition on nanowire surfaces modified by the self-assembled monolayer

    T. Shimada, T. Yasui, A. Yokoyama, T. Goda, M. Hara, T. Yanagida, N. Kaji, M. Kanai, K. Nagashima, Y. Miyahara, T. Kawai and Y. Baba, Lab Chip, 2018, Advance Article , DOI: 10.1039/C8LC00438B

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