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Issue 13, 2018
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Nitrate measurement in droplet flow: gas-mediated crosstalk and correction

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Abstract

In droplet microfluidics, droplets have traditionally been considered discrete self-contained reaction chambers, however recent work has shown that dissolved solutes can transfer into the oil phase and migrate into neighbouring droplets under certain conditions. The majority of reports on such inter-droplet “crosstalk” have focused on surfactant-driven mechanisms, such as transport within micelles. While trialling a droplet-based system for quantifying nitrate in water, we encountered crosstalk driven by a very different mechanism: conversion of the analyte to a gaseous intermediate which subsequently diffused between droplets. Importantly we found that the crosstalk occurred predictably, could be experimentally quantified, and measurements rationally post-corrected. This showed that droplet microfluidic systems susceptible to crosstalk such as this can nonetheless be used for quantitative analysis.

Graphical abstract: Nitrate measurement in droplet flow: gas-mediated crosstalk and correction

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Publication details

The article was received on 24 Jan 2018, accepted on 01 Jun 2018 and first published on 04 Jun 2018


Article type: Paper
DOI: 10.1039/C8LC00092A
Citation: Lab Chip, 2018,18, 1903-1913
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    Nitrate measurement in droplet flow: gas-mediated crosstalk and correction

    A. M. Nightingale, S. Hassan, G. W. H. Evans, S. M. Coleman and X. Niu, Lab Chip, 2018, 18, 1903
    DOI: 10.1039/C8LC00092A

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