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Issue 9, 2018
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Teratogen screening with human pluripotent stem cells

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Abstract

Birth defects are a common occurrence in the United States and worldwide. Currently, evaluation of potential developmental toxicants (i.e., teratogens) relies heavily on animal-based models which do not always adequately mimic human development. In order to address this, researchers are developing in vitro human-based models which utilize human pluripotent stem cells (hPSCs) to assess the teratogenic potential of chemical substances. The field of human developmental toxicity assays includes a variety of platforms including monolayer, micropattern, embryoid body, and 3D organoid cultures. In this review, we will overview the field of human teratogenic assays, detail the most recent advances, and discuss current limitations and future perspectives.

Graphical abstract: Teratogen screening with human pluripotent stem cells

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Publication details

The article was received on 08 May 2018, accepted on 30 Jul 2018 and first published on 31 Jul 2018


Article type: Review Article
DOI: 10.1039/C8IB00082D
Citation: Integr. Biol., 2018,10, 491-501

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