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Metabonomics analysis of quercetin against the nephrotoxicity of acrylamide in rat

Abstract

This research aimed to analyse the protective effect of quercetin against the nephrotoxicity of acrylamide (AA) using metabonomics technology. Rats were randomly divided into six groups, including the control group, AA-treated group (5 mg/kg.bw/d), two dosages of quercetin-treated groups (10 and 50 mg/kg.bw/d) and two dosages of quercetin plus AA-treated groups. Quercetin and AA were administered to rats daily via gavage and drinking water, respectively. After a 16 week treatment, kidneys were collected for metabonomics analysis. A total of 14 metabolites were identified in positive and negative modes via the metabonomics profiles of kidney tissues. Compared with the control group, the intensities of uric acid, 6,8-dihydroxypurine, hypoxanthine, guanosine, L-phenylalanine, succinyladenosine, tryptophan, lysophosphatidylcholines (LPC(16:0), LPC(18:1(9z)), LPC(18:2(9z,12z))) and inosine in the AA-treated group were significantly increased (p < 0.01); and the intensities of L-acetylcarnitine, 2-phenylacetamide and pantothenic acid in the AA-treated group were decreased (p < 0.01). However, the intensities of the previously mentioned metabolites had the opposite trends in the high-dose quercetin (50 mg/kg.bw/d) plus AA-treated group (p < 0.01 or p < 0.05). Results showed that quercetin exerted protective effects on AA-induced nephrotoxicity by enhancing the antioxidant defence system of the body and regulating phospholipid, energy and amino acid metabolism.

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Publication details

The article was received on 08 May 2018, accepted on 08 Oct 2018 and first published on 10 Oct 2018


Article type: Paper
DOI: 10.1039/C8FO00902C
Citation: Food Funct., 2018, Accepted Manuscript
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    Metabonomics analysis of quercetin against the nephrotoxicity of acrylamide in rat

    L. Bo, Y. Liu, S. Jia, Y. Liu, M. zhang, S. Li, X. Zhao and C. Sun, Food Funct., 2018, Accepted Manuscript , DOI: 10.1039/C8FO00902C

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