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Volume 210, 2018
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Biomimetic ion channels formation by emulsion based on chemically modified cyclodextrin nanotubes

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Abstract

Biomimetic ion channels can be made to display the high sensitivity of natural protein nanopores and to develop new properties as a function of the material used. How to design the best future biomimetic channels? The main challenges are to control their sensitivity, as well as their syntheses, chemical modifications, insertion and lifetime in a lipid membrane. To address these challenges, we have recently designed short cyclodextrin nanotubes characterized by mass spectrometry and high-resolution transmission electron microscopy. They form non-permanent ion channels in lipid bilayers. Here we show how to improve the nanotube insertion in order to limit multiple insertions, how to stabilize biomimetic channels into the membrane, and how to understand the ion dynamics in confined medium scale.

Graphical abstract: Biomimetic ion channels formation by emulsion based on chemically modified cyclodextrin nanotubes

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Article information


Submitted
15 Feb 2018
Accepted
26 Mar 2018
First published
26 Mar 2018

Faraday Discuss., 2018,210, 41-54
Article type
Paper

Biomimetic ion channels formation by emulsion based on chemically modified cyclodextrin nanotubes

L. Bacri, H. Mamad-Hemouch, C. Przybylski, B. Thiébot, G. Patriarche, N. Jarroux and J. Pelta, Faraday Discuss., 2018, 210, 41
DOI: 10.1039/C8FD00030A

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