Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 27th March 2019 from 11:00 AM to 1:00 PM (GMT).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.

Issue 42, 2018
Previous Article Next Article

Copper(II) complexes for cysteine detection using 19F magnetic resonance

Author affiliations


Cysteine plays an essential role in maintaining cellular redox homeostasis and perturbations in cysteine concentration are associated with cardiovascular disease, liver disease, and cancer. 19F MRI is a promising modality for detecting cysteine in biology due to its high tissue penetration and negligible biological background signal. Herein we report fluorinated macrocyclic copper complexes that display a 19F NMR/MRI turn-on response following reduction of the Cu(II) complexes by cysteine. The reactivity with cysteine was studied by monitoring the appearance of a robust diamagnetic 19F signal following addition of cysteine in conjunction with UV-vis and EPR spectroscopies. Importantly, complexes with –CH2CF3 tags display good water solubility. Studies with this complex in HeLa cells demonstrate the applicability of these probes to detect cysteine in complex biological environments.

Graphical abstract: Copper(ii) complexes for cysteine detection using 19F magnetic resonance

Back to tab navigation

Supplementary files

Publication details

The article was received on 18 Sep 2018, accepted on 29 Sep 2018 and first published on 04 Oct 2018

Article type: Paper
DOI: 10.1039/C8DT03780A
Citation: Dalton Trans., 2018,47, 15024-15030

  •   Request permissions

    Copper(II) complexes for cysteine detection using 19F magnetic resonance

    J. S. Enriquez, M. Yu, B. S. Bouley, D. Xie and E. L. Que, Dalton Trans., 2018, 47, 15024
    DOI: 10.1039/C8DT03780A

Search articles by author