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Issue 43, 2018
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Synthesis of novel heteroleptic delocalised cationic pyrazole gold complexes as potent HepG2 cytotoxic agents

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Abstract

A new series of cationic gold(I) pyrazole complexes were prepared in excellent yields as their perchlorate salts. Results of cell viability assays show that these novel complexes have good cytotoxic properties against the human HepG2 cancer cell line. These complexes showed promising anti-cancer activities and to our knowledge, pyrazoles have never been tested against this cell line. The regioselectivity of the complexation is also discussed in regards to the substitution pattern of the pyrazoles.

Graphical abstract: Synthesis of novel heteroleptic delocalised cationic pyrazole gold complexes as potent HepG2 cytotoxic agents

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Publication details

The article was received on 10 Jul 2018, accepted on 26 Sep 2018 and first published on 26 Sep 2018


Article type: Paper
DOI: 10.1039/C8DT02832J
Citation: Dalton Trans., 2018,47, 15338-15343
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    Synthesis of novel heteroleptic delocalised cationic pyrazole gold complexes as potent HepG2 cytotoxic agents

    F. Afolabi, W. Souissi, G. Rivière, C. Lemaitre, S. M. Roe, N. Crickmore and E. M. E. Viseux, Dalton Trans., 2018, 47, 15338
    DOI: 10.1039/C8DT02832J

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