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Issue 25, 2018
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A silver metal complex as a luminescent probe for enzymatic sensing of glucose in blood plasma and urine

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Abstract

In this work, we present a facile preparation of a paper-based glucose assay for rapid, sensitive, and quantitative measurement of glucose in blood plasma and urine. Two copper phosphorescent complexes [Cu(2,9-dimethyl-4,7-diphenyl-1,10-phenanthroline)(2,6-dimethylphenylisocyanide)2][B(C6H3(CF3)2)4] (Cu1) and [Cu(2,9-dimethyl-1,10-phenanthroline)(2,6-dimethylphenylisocyanide)2][B(C6H3(CF3)2)4] (Cu2) and a new silver congener [Ag(P3)CNAg(P3)][B(C6H3(CF3)2)4] (Ag3) (P3 = PPh2C6H4-PPh-C6H4PPh2 [bis(o-diphenylphosphinophenyl)phenylphosphine]) have been synthesized and their oxygen sensing abilities were investigated. The dimetallic phosphine-based Ag3 complex, having a high oxygen sensing ability, was employed as an efficient signal transducer in enzymatic reactions to recognize blood plasma glucose and urine glucose, which provided a wide linear response for a concentration range between 1.0 and 35 mM and a rapid response, with a limit of detection (LOD) of 0.09 mM for glucose. In practical application, this Ag3 paper-based device offers great analytical reliability and accuracy upon monitoring glucose concentrations in blood plasma.

Graphical abstract: A silver metal complex as a luminescent probe for enzymatic sensing of glucose in blood plasma and urine

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Publication details

The article was received on 06 Feb 2018, accepted on 26 May 2018 and first published on 28 May 2018


Article type: Paper
DOI: 10.1039/C8DT00500A
Citation: Dalton Trans., 2018,47, 8346-8355
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    A silver metal complex as a luminescent probe for enzymatic sensing of glucose in blood plasma and urine

    Z. Pan, Y. Wang, G. Chakkaradhari, J. F. Zhu, R. He, Y. Liu, C. Hsu, I. O. Koshevoy, P. Chou, S. Pan and M. Ho, Dalton Trans., 2018, 47, 8346
    DOI: 10.1039/C8DT00500A

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