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Third generation antibody discovery methods: in silico rational design

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Abstract

Owing to their outstanding performances in molecular recognition, antibodies are extensively used in research and applications in molecular biology, biotechnology and medicine. Recent advances in experimental and computational methods are making it possible to complement well-established in vivo (first generation) and in vitro (second generation) methods of antibody discovery with novel in silico (third generation) approaches. Here we describe the principles of computational antibody design and review the state of the art in this field. We then present Modular, a method that implements the rational design of antibodies in a modular manner, and describe the opportunities offered by this approach.

Graphical abstract: Third generation antibody discovery methods: in silico rational design

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Publication details

The article was received on 25 Jun 2018 and first published on 09 Oct 2018


Article type: Review Article
DOI: 10.1039/C8CS00523K
Citation: Chem. Soc. Rev., 2018, Advance Article
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    Third generation antibody discovery methods: in silico rational design

    P. Sormanni, F. A. Aprile and M. Vendruscolo, Chem. Soc. Rev., 2018, Advance Article , DOI: 10.1039/C8CS00523K

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