Jump to main content
Jump to site search

Issue 18, 2018
Previous Article Next Article

Investigating supramolecular systems using Förster resonance energy transfer

Author affiliations

Abstract

Supramolecular systems have applications in areas as diverse as materials science, biochemistry, analytical chemistry, and nanomedicine. However, analyzing such systems can be challenging due to the wide range of time scales, binding strengths, distances, and concentrations at which non-covalent phenomena take place. Due to their versatility and sensitivity, Förster resonance energy transfer (FRET)-based techniques are excellently suited to meet such challenges. Here, we detail the ways in which FRET has been used to study non-covalent interactions in both synthetic and biological supramolecular systems. Among other topics, we examine methods to measure molecular forces, determine protein conformations, monitor assembly kinetics, and visualize in vivo drug release from nanoparticles. Furthermore, we highlight multiplex FRET techniques, discuss the field's limitations, and provide a perspective on new developments.

Graphical abstract: Investigating supramolecular systems using Förster resonance energy transfer

Back to tab navigation

Publication details

The article was received on 23 May 2018 and first published on 09 Aug 2018


Article type: Review Article
DOI: 10.1039/C8CS00278A
Citation: Chem. Soc. Rev., 2018,47, 7027-7044
  •   Request permissions

    Investigating supramolecular systems using Förster resonance energy transfer

    A. J. P. Teunissen, C. Pérez-Medina, A. Meijerink and W. J. M. Mulder, Chem. Soc. Rev., 2018, 47, 7027
    DOI: 10.1039/C8CS00278A

Search articles by author

Spotlight

Advertisements