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Issue 21, 2018
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Recent advances in the application of Diels–Alder reactions involving o-quinodimethanes, aza-o-quinone methides and o-quinone methides in natural product total synthesis

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Abstract

In recent decades, transient and highly reactive ortho-quinodimethanes (o-QDMs), ortho-quinone methides (o-QMs) and aza-ortho-quinone methides (aza-o-QMs) have attracted much attention and have been extensively studied and applied in organic synthesis, especially natural product total synthesis. This review summarizes recent advances in Diels–Alder reactions involving in situ-generated o-QDMs, o-QMs and aza-o-QMs, highlighting the power and potential of this strategy in organic synthesis and natural product total synthesis. An overview of the methods for generating these intermediates is also available.

Graphical abstract: Recent advances in the application of Diels–Alder reactions involving o-quinodimethanes, aza-o-quinone methides and o-quinone methides in natural product total synthesis

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Publication details

The article was received on 08 Apr 2018 and first published on 11 Jul 2018


Article type: Review Article
DOI: 10.1039/C8CS00274F
Citation: Chem. Soc. Rev., 2018,47, 7926-7953
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    Recent advances in the application of Diels–Alder reactions involving o-quinodimethanes, aza-o-quinone methides and o-quinone methides in natural product total synthesis

    B. Yang and S. Gao, Chem. Soc. Rev., 2018, 47, 7926
    DOI: 10.1039/C8CS00274F

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