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Issue 10, 2018
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Tailoring lumazine synthase assemblies for bionanotechnology

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Nanoscale compartments formed by hierarchical protein self-assembly are valuable platforms for nanotechnology development. The well-defined structure and broad chemical functionality of protein cages, as well as their amenability to genetic and chemical modification, have enabled their repurposing for diverse applications. In this review, we summarize progress in the engineering of the cage-forming enzyme lumazine synthase. This bacterial nanocompartment has proven to be a malleable scaffold. The natural protein has been diversified to afford a family of unique proteinaceous capsules that have been modified, evolved and assembled with other components to produce nanoreactors, artificial organelles, delivery vehicles and virus mimics.

Graphical abstract: Tailoring lumazine synthase assemblies for bionanotechnology

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Publication details

The article was received on 22 Feb 2018 and first published on 01 May 2018

Article type: Review Article
DOI: 10.1039/C8CS00154E
Citation: Chem. Soc. Rev., 2018,47, 3543-3557
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    Tailoring lumazine synthase assemblies for bionanotechnology

    Y. Azuma, T. G. W. Edwardson and D. Hilvert, Chem. Soc. Rev., 2018, 47, 3543
    DOI: 10.1039/C8CS00154E

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