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Issue 18, 2018
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Self-immolative colorimetric, fluorescent and chemiluminescent chemosensors

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Self-immolative chemistry features a cascade of disassembly reactions in response to external stimuli, which provides great opportunities to design new self-immolative chemosensors with advanced performance and/or functions. Self-immolative spacers in these chemosensors not only facilitate the linkage of designed triggers to various chromophores or fluorophores, but can also be used to solve inherent problems associated with native chemosensors, such as low reactivities, poor stabilities and slow response times. Their capacity for stimuli-responsive release through operation of a self-immolative reaction further enables integration of sophisticated functions into chemosensors, including signal amplification, enzyme activity localization, and drug monitoring. Significant advances have been made in the field of self-immolative chemosensors, leading to intriguing applications to sensitive detection of analytes, bioimaging and cancer theranostics. This tutorial review summarizes this recent progress with a focus on their design strategies and sensing mechanisms.

Graphical abstract: Self-immolative colorimetric, fluorescent and chemiluminescent chemosensors

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Publication details

The article was received on 30 May 2018 and first published on 03 Sep 2018

Article type: Tutorial Review
DOI: 10.1039/C7CS00841D
Citation: Chem. Soc. Rev., 2018,47, 6900-6916

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    Self-immolative colorimetric, fluorescent and chemiluminescent chemosensors

    J. Yan, S. Lee, A. Zhang and J. Yoon, Chem. Soc. Rev., 2018, 47, 6900
    DOI: 10.1039/C7CS00841D

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