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The Effect of Electrostatic Interactions on the Formation of Pharmaceutical Eutectics

Abstract

Over the past decade the formation of pharmaceutical eutectics has become a very attractive strategy to increase bioavailability of active pharmaceutical ingredients (APIs). A great advantage of a eutectic phase, which can be obtained by simple physical mixing of solid materials, is the possibility to attain a material with desired physicochemical properties only by varying the molar ratio of the parent components. In this work, we have investigated the ability of two protic ionic liquids (PILs), which are hydrochloride salts of lidocaine and prilocaine, as well as their non-ionic counterparts, to form eutectic mixtures. To get an insight into the calorimetric properties of the formed dipolar and ionic mixtures, differential scanning calorimetry was employed. The mechanism of formation of deep eutectic mixtures on the molecular lever was investigated by ab initio quantum mechanics calculations. The effect of electrostatic interactions on the eutectic transition, glass forming ability, physical stability of pharmaceutical eutectics was also revealed.

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Publication details

The article was accepted on 08 Oct 2018 and first published on 10 Oct 2018


Article type: Paper
DOI: 10.1039/C8CP05905E
Citation: Phys. Chem. Chem. Phys., 2018, Accepted Manuscript
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    The Effect of Electrostatic Interactions on the Formation of Pharmaceutical Eutectics

    Z. Wojnarowska, W. Smolka, J. Zotova, J. Knapik, A. Sherif, L. Tajber and M. Paluch, Phys. Chem. Chem. Phys., 2018, Accepted Manuscript , DOI: 10.1039/C8CP05905E

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