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Capturing a new hydrate polymorph of amodiaquine dihydrochloride dihydrate via heterogeneous crystallisation

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Abstract

Herein, we report a new polymorph of amodiaquine dihydrochloride dihydrate obtained via heterogeneous crystallisation. This new polymorph exhibits similarity in molecular conformation as well as in its one-dimensional chain structure with a previously known polymorph, however with a difference in its two-dimensional sheet structure. Although crystal DFT-calculations predict the new form to be thermodynamically less stable compared to the previously known polymorph, the preparation method applied opened up the access to its metastable zone.

Graphical abstract: Capturing a new hydrate polymorph of amodiaquine dihydrochloride dihydrate via heterogeneous crystallisation

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Publication details

The article was received on 09 Oct 2018, accepted on 27 Nov 2018 and first published on 27 Nov 2018


Article type: Communication
DOI: 10.1039/C8CE01720D
Citation: CrystEngComm, 2019, Advance Article
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    Capturing a new hydrate polymorph of amodiaquine dihydrochloride dihydrate via heterogeneous crystallisation

    O. D. Putra, A. Pettersen, S. O. Nilsson Lill, D. Umeda, E. Yonemochi, Y. P. Nugraha and H. Uekusa, CrystEngComm, 2019, Advance Article , DOI: 10.1039/C8CE01720D

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