Jump to main content
Jump to site search


Stanozolol–aromatic carboxylic acid crystalline complexes: flexible tautomeric/ionization states and supramolecular synthons

Author affiliations

Abstract

Stanozolol (STAN) is an androgenic and anabolic steroid medication used for the treatment of anemia, osteoporosis, and hereditary angioedema. This weakly basic compound possesses two energy-equivalent tautomers. These tautomeric forms and neutral/cationic states of STAN allow the presence of diverse intermolecular interactions in its crystalline complexes. Two salts and five cocrystals of STAN have been reported with acidic guest molecules. Here, five novel crystalline complexes of STAN with benzoic acid derivatives, 2,6-dihydroxybenzoic acid (DBA), 2,5-dihydroxybenzoic acid (DHA), 1,2-benzenedicarboxylic acid (PHA), and gallic acid (GA), were successfully prepared. The molecular states of STAN and supramolecular synthons in these solid forms were disclosed via the solved single crystal structures and the 13C solid state NMR spectra. Additionally, all the new anhydrous crystalline phases demonstrated favourable thermal stability and physical stability against hydration.

Graphical abstract: Stanozolol–aromatic carboxylic acid crystalline complexes: flexible tautomeric/ionization states and supramolecular synthons

Back to tab navigation

Supplementary files

Publication details

The article was received on 27 Aug 2018, accepted on 30 Nov 2018 and first published on 03 Dec 2018


Article type: Paper
DOI: 10.1039/C8CE01439F
Citation: CrystEngComm, 2019, Advance Article
  •   Request permissions

    Stanozolol–aromatic carboxylic acid crystalline complexes: flexible tautomeric/ionization states and supramolecular synthons

    X. Wang, M. Kong, D. Li, J. Fang, Z. Deng and H. Zhang, CrystEngComm, 2019, Advance Article , DOI: 10.1039/C8CE01439F

Search articles by author

Spotlight

Advertisements