Controlled synthesis of Fe3O4@ZIF-8 nanoparticles for drug delivery

Guihuan Chen; Bing Yu; Chenghao Lu; Haohao Zhang; Youqing Shen; Hailin Cong

doi:10.1039/C8CE01302K

Controlled synthesis of Fe₃O₄@ZIF-8 nanoparticles for drug delivery†

Guihuan Chen,^a Bing Yu,

^ab Chenghao Lu,^a Haohao Zhang,^a Youqing Shen^ac and Hailin Cong

*^ab

Author affiliations

* Corresponding authors

^a Institute of Biomedical Materials and Engineering, College of Materials Science and Engineering, College of Chemistry and Chemical Engineering, Qingdao University, Qingdao 266071, China
E-mail: conghailin@qdu.edu.cn
Tel: +86 532 8595 3995

^b Laboratory for New Fiber Materials and Modern Textile, Growing Base for State Key Laboratory, Qingdao University, Qingdao 266071, China

^c Key Laboratory of Biomass Chemical Engineering of Ministry of Education, Center for Bionanoengineering and Department of Chemical and Biological Engineering, Zhejiang University, Hangzhou, Zhejiang, China

Abstract

Encapsulating well-defined nanoparticles (NPs) into ZIF-8 to form core–shell structures not only can minimize the drawbacks and maximize the advantages of the disparate components but also may provide synergistic functionality. This work presents novel one-pot synthetic methods to produce Fe₃O₄@ZIF-8 NPs. Moreover, the morphology of Fe₃O₄@ZIF-8 NPs can be easily controlled by changing the synthesis conditions (time, temperature, and dosage). The as-obtained Fe₃O₄@ZIF-8 NPs have good dispersibility and a large specific surface area and they are proven to have potential applications as drug delivery models with good biocompatibility, high drug loading and good pH responsiveness.

This article is part of the themed collection: Editor’s Collection: Bio-applications of MOFs

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Article information

DOI: https://doi.org/10.1039/C8CE01302K
Article type: Paper
Submitted: 04 Aug 2018
Accepted: 08 Oct 2018
First published: 09 Oct 2018

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CrystEngComm, 2018,20, 7486-7491

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Controlled synthesis of Fe₃O₄@ZIF-8 nanoparticles for drug delivery

G. Chen, B. Yu, C. Lu, H. Zhang, Y. Shen and H. Cong, CrystEngComm, 2018, 20, 7486 DOI: 10.1039/C8CE01302K

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