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Issue 35, 2018
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Amine–carboxylate supramolecular synthon in pharmaceutical cocrystals

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Abstract

Carboxylate moieties are less considered in the field of pharmaceutical cocrystal research, although they are contained in some important drug substances and cocrystal formers. Here, we demonstrated that an amine–carboxylate intermolecular interaction (N–H⋯OOC) can be used as a supramolecular synthon for pharmaceutical cocrystal design.

Graphical abstract: Amine–carboxylate supramolecular synthon in pharmaceutical cocrystals

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Supplementary files

Article information


Submitted
05 Jul 2018
Accepted
14 Aug 2018
First published
14 Aug 2018

CrystEngComm, 2018,20, 5112-5118
Article type
Communication

Amine–carboxylate supramolecular synthon in pharmaceutical cocrystals

D. Li, M. Kong, J. Li, Z. Deng and H. Zhang, CrystEngComm, 2018, 20, 5112
DOI: 10.1039/C8CE01106K

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