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Issue 13, 2019
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Site-selective conversion of azido groups at carbonyl α-positions into oxime groups leading triazide to a triple click conjugation scaffold

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Abstract

This paper reports the selective conversion of alkyl azido groups at the carbonyl α-position into oximes through β-elimination of dinitrogen, followed by transoximation. With this method and diazo conversion, a triazido molecule was transformed into a triple click conjugation scaffold allowing one-pot four-component coupling.

Graphical abstract: Site-selective conversion of azido groups at carbonyl α-positions into oxime groups leading triazide to a triple click conjugation scaffold

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Publication details

The article was received on 27 Nov 2018, accepted on 12 Dec 2018 and first published on 13 Dec 2018


Article type: Communication
DOI: 10.1039/C8CC09415B
Citation: Chem. Commun., 2019,55, 1891-1894

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    Site-selective conversion of azido groups at carbonyl α-positions into oxime groups leading triazide to a triple click conjugation scaffold

    T. Yokoi, T. Ueda, H. Tanimoto, T. Morimoto and K. Kakiuchi, Chem. Commun., 2019, 55, 1891
    DOI: 10.1039/C8CC09415B

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