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Dynamic split G-quadruplex programmed reversible nanodevice

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Abstract

We propose a dynamic nanodevice based on a split G-quadruplex (G4). By splitting it apart, we can successfully decouple the G-tetrad formation from external stimuli, greatly expanding the stimulus for G4 based devices. Taking advantage of the rigid force from a DNA duplex, the nanodevice can be switched reversibly through the conformational transformation.

Graphical abstract: Dynamic split G-quadruplex programmed reversible nanodevice

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Publication details

The article was received on 02 Nov 2018, accepted on 03 Dec 2018 and first published on 04 Dec 2018


Article type: Communication
DOI: 10.1039/C8CC08744J
Citation: Chem. Commun., 2019, Advance Article
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    Dynamic split G-quadruplex programmed reversible nanodevice

    Y. Yu, Y. Zhou, M. Zhu, G. Su, H. Deng, W. Chen and H. Peng, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C8CC08744J

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