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Issue 98, 2018
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A pH-driven ring translocation switch against cancer cells

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Abstract

A molecular switch built with cucurbit[7]uril and a 3-station viologen-phenylene-imidazole compound exhibited pH actuated ring translocation with high fatigue resistance (up to 102 cycles). The switch movement was harnessed toward selectively masking the toxicity of the viologen fragment at neutral pH near non-cancerous cells, while exposing it at acid pH near cancer cells.

Graphical abstract: A pH-driven ring translocation switch against cancer cells

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Publication details

The article was received on 30 Oct 2018, accepted on 14 Nov 2018 and first published on 15 Nov 2018


Article type: Communication
DOI: 10.1039/C8CC08681H
Chem. Commun., 2018,54, 13825-13828

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    A pH-driven ring translocation switch against cancer cells

    Q. Cheng, H. Yin, R. Rosas, D. Gigmes, O. Ouari, R. Wang, A. Kermagoret and D. Bardelang, Chem. Commun., 2018, 54, 13825
    DOI: 10.1039/C8CC08681H

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