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Selenols: A new class of Carbonic Anhydrase inhibitors

Abstract

Stable aryl selenols were obtained through a convenient procedure. Selenols represent a new chemotype acting as carbonic anhydrase inhibitors (CAIs), inhibiting four human isoforms, CAs I, II, VII and the tumor-associated CA IX. X-ray crystallographic, physical and computational studies provided insights into the binding mode of this conceptually new class of CAIs.

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Publication details

The article was received on 31 Oct 2018, accepted on 03 Dec 2018 and first published on 06 Dec 2018


Article type: Communication
DOI: 10.1039/C8CC08562E
Citation: Chem. Commun., 2018, Accepted Manuscript
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    Selenols: A new class of Carbonic Anhydrase inhibitors

    A. Angeli, D. Tanini, A. Nocentini, M. Ferraroni, A. Capperucci, P. Gratteri and C. Supuran, Chem. Commun., 2018, Accepted Manuscript , DOI: 10.1039/C8CC08562E

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