Issue 5, 2019
From the journal:

Chemical Communications

Selenols: a new class of carbonic anhydrase inhibitors†

Andrea Angeli,‡a   Damiano Tanini, ORCID logo ‡b   Alessio Nocentini,ac   Antonella Capperucci,b   Marta Ferraroni,b   Paola Gratteri ORCID logo ac  and  Claudiu T. Supuran ORCID logo *a  

* Corresponding authors

a University of Florence, NEUROFARBA Department, Sezione di Scienze Farmaceutiche, Via Ugo Schiff 6, 50019 Sesto Fiorentino, Florence, Italy
E-mail: claudiu.supuran@unifi.it

b University of Florence, Department of Chemistry “Ugo Schiff”, Via della Lastruccia 13, I-50019 Sesto Fiorentino, Italy

c University of Florence, NEUROFARBA – Pharmaceutical and Nutraceutical Section, Laboratory of Molecular Modeling Cheminformatics & QSAR, Via Ugo Schiff 6, 50019 Sesto Fiorentino, Florence, Italy

Abstract

Stable aryl selenols were obtained through a convenient procedure. Selenols represent a new chemotype acting as carbonic anhydrase inhibitors (CAIs), inhibiting four human isoforms, CAs I, II, VII and the tumor-associated CA IX. X-ray crystallographic, physical and computational studies provided insights into the binding mode of this conceptually new class of CAIs.

Graphical abstract: Selenols: a new class of carbonic anhydrase inhibitors

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Article information

DOI
https://doi.org/10.1039/C8CC08562E
Article type
Communication
Submitted
31 Oct 2018
Accepted
03 Dec 2018
First published
06 Dec 2018

Chem. Commun., 2019,55, 648-651

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Selenols: a new class of carbonic anhydrase inhibitors

A. Angeli, D. Tanini, A. Nocentini, A. Capperucci, M. Ferraroni, P. Gratteri and C. T. Supuran, Chem. Commun., 2019, 55, 648 DOI: 10.1039/C8CC08562E

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