Jump to main content
Jump to site search


Directly Monitoring the Active Sites of Charge Transfer in Heterocycles in Situ and in Real Time

Abstract

Determination of the active sites of charge transfer(CT) is the key to understand the reactivity and stacking interaction; but it remains technically challenging. Here, we demonstrate that a newly developed coherent degenerate infrared-infrared-visible sum frequency generation vibrational spectroscopy (DIIV-SFG) provides a powerful label-free sensitive probe for CT active sites in heterocyclic molecules in situ and in real time. Using flavins as models, it is found that the DIIV-SFG spectra generated by picosecond laser are dominated by the vibrational modes that are coupled through the electronic states. These modes are associated with the most electrophilic sites of flavins. The influences of flavin mononucleotide (FMN) concentration, solvent, metal ion binding, and redox reaction on the DIIV-SFG spectra allow to directly observe the site-specific change of electronic structures in flavins induced by the environment. It is expected that DIIV-SFG spectroscopy may open up a new spectral window to monitor the CT processes in biological heterocyclic systems.

Back to tab navigation

Supplementary files

Publication details

The article was received on 23 Oct 2018, accepted on 06 Dec 2018 and first published on 06 Dec 2018


Article type: Communication
DOI: 10.1039/C8CC08452A
Citation: Chem. Commun., 2018, Accepted Manuscript
  •   Request permissions

    Directly Monitoring the Active Sites of Charge Transfer in Heterocycles in Situ and in Real Time

    S. Ye, J. Tan, K. Tian, C. Li, J. Zhang and Y. Luo, Chem. Commun., 2018, Accepted Manuscript , DOI: 10.1039/C8CC08452A

Search articles by author

Spotlight

Advertisements