Issue 4, 2019

Visible-light mediated carbamoyl radical addition to heteroarenes

Abstract

The generation of carbamoyl radicals, followed by their addition to heteroarenes, was performed under mild conditions through a metal-free photocatalyzed decarboxylation of oxamic acids. The process has been applied to the carbamoylation of heteroaromatic bases using α-aminoacid-derived oxamic acids, leading to the corresponding amides without racemization.

Graphical abstract: Visible-light mediated carbamoyl radical addition to heteroarenes

Supplementary files

Article information

Article type
Communication
Submitted
17 Oct 2018
Accepted
05 Dec 2018
First published
06 Dec 2018

Chem. Commun., 2019,55, 466-469

Visible-light mediated carbamoyl radical addition to heteroarenes

A. H. Jatoi, G. G. Pawar, F. Robert and Y. Landais, Chem. Commun., 2019, 55, 466 DOI: 10.1039/C8CC08326F

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