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Desferrioxamine:Gallium-Pluronic Micelles Increase Outer Membrane Permeability and Potentiate Antibiotic Activity Against Pseudomonas aeruginosa

Abstract

The outer membrane of Pseudomonas aeruginosa functions primarily as a permeability barrier and imparts a broad spectrum of intrinsic antibiotic resistance. Herein, we describe the synthesis, characterization, and antimicrobial evaluation of a targeted polymeric micelle that specifically permeabilizes the outer membrane and potentiates antibiotic activity against P. aeruginosa.

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Publication details

The article was received on 10 Oct 2018, accepted on 08 Nov 2018 and first published on 08 Nov 2018


Article type: Communication
DOI: 10.1039/C8CC08134D
Citation: Chem. Commun., 2018, Accepted Manuscript
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    Desferrioxamine:Gallium-Pluronic Micelles Increase Outer Membrane Permeability and Potentiate Antibiotic Activity Against Pseudomonas aeruginosa

    M. Purro, J. Qiao, Z. Liu, M. M. Ashcraft and M. Xiong, Chem. Commun., 2018, Accepted Manuscript , DOI: 10.1039/C8CC08134D

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