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J-Aggregate squaraine nanoparticles with bright NIR-II fluorescence for imaging guided photothermal therapy

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Abstract

We introduce a novel strategy to enhance the fluorescence brightness of organic-molecule-based nanoparticles in the second near-infrared window (NIR-II, 1000–1700 nm) by fabricating J-aggregate nanoparticles SQP-NPs(J). Our prepared J-aggregate nanoparticles SQP-NPs(J) show an emission maximum near 1100 nm, and the emission intensity is 4.8-fold higher than that of H-aggregate SQP-NPs(H). In addition, SQP-NPs(J) can be used for NIR-II imaging guided photothermal therapy on MCF-7 tumor-bearing mice due to the fact that SQP-NPs(J) have highly effective photothermal properties, which are significant for precise tumor diagnostics and treatments.

Graphical abstract: J-Aggregate squaraine nanoparticles with bright NIR-II fluorescence for imaging guided photothermal therapy

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Publication details

The article was received on 10 Oct 2018, accepted on 07 Nov 2018 and first published on 08 Nov 2018


Article type: Communication
DOI: 10.1039/C8CC08096H
Citation: Chem. Commun., 2018, Advance Article
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    J-Aggregate squaraine nanoparticles with bright NIR-II fluorescence for imaging guided photothermal therapy

    P. Sun, Q. Wu, X. Sun, H. Miao, W. Deng, W. Zhang, Q. Fan and W. Huang, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C8CC08096H

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