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Issue 95, 2018
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Assembly of glycoamino acid building blocks: a new strategy for the straightforward synthesis of heparan sulfate mimics

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Abstract

A new strategy that enables a modular straightforward synthesis of heparan sulfate oligosaccharide mimics by the assembly of simple glycoamino acid building blocks is described. The coupling between units is readily carried out by an amidation reaction. Several glycoamino acid oligomers were prepared and their interaction with the FGF2 protein was analyzed.

Graphical abstract: Assembly of glycoamino acid building blocks: a new strategy for the straightforward synthesis of heparan sulfate mimics

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Publication details

The article was received on 09 Oct 2018, accepted on 08 Nov 2018 and first published on 08 Nov 2018


Article type: Communication
DOI: 10.1039/C8CC08067D
Citation: Chem. Commun., 2018,54, 13455-13458

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    Assembly of glycoamino acid building blocks: a new strategy for the straightforward synthesis of heparan sulfate mimics

    J. Revuelta, R. Fuentes, L. Lagartera, M. J. Hernáiz, A. Bastida, E. García-Junceda and A. Fernández-Mayoralas, Chem. Commun., 2018, 54, 13455
    DOI: 10.1039/C8CC08067D

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