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Mn(II)-catalysed alkylation of methylene ketones with alcohols: direct access to functionalised branched products

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Abstract

Herein an operationally simple alkylation of methylene ketones with primary alcohols is reported. Use of an inexpensive and earth abundant Mn/1,10-phenanthroline system enables direct access to a series of functionalised branched ketones including one-pot sequential double alkylation and Alzheimer's drug donepezil. Preliminary mechanistic investigation, determination of the rate and order of reactions and deuterium labeling experiments support the participation of the hydrogen-borrowing strategy for the ketone alkylation.

Graphical abstract: Mn(ii)-catalysed alkylation of methylene ketones with alcohols: direct access to functionalised branched products

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Publication details

The article was received on 07 Oct 2018, accepted on 25 Oct 2018 and first published on 25 Oct 2018


Article type: Communication
DOI: 10.1039/C8CC08010K
Citation: Chem. Commun., 2018, Advance Article
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    Mn(II)-catalysed alkylation of methylene ketones with alcohols: direct access to functionalised branched products

    L. M. Kabadwal, J. Das and D. Banerjee, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C8CC08010K

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