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High-depth fluorescence imaging using two-photon FRET system for mitochondrial pH in live cells and tissues

Abstract

We developed a fluorescent pH probe (1) capable of two-photon excitability and far-visible-emission based on FRET, composed of naphthalimide-piperazine-rhodamine. It exhibited a pH-dependent reversible and fast ratiometric fluorescent change in the rhodamine emission. Probe 1 was applied to image the pH perturbations of mitochondria in living cells and tissues.

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Publication details

The article was received on 04 Oct 2018, accepted on 06 Nov 2018 and first published on 07 Nov 2018


Article type: Communication
DOI: 10.1039/C8CC07934J
Citation: Chem. Commun., 2018, Accepted Manuscript
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    High-depth fluorescence imaging using two-photon FRET system for mitochondrial pH in live cells and tissues

    M. J. Chang, K. Kim, K. S. Park, J. S. Kang, C. S. Lim, H. M. Kim, C. Kang and M. Lee, Chem. Commun., 2018, Accepted Manuscript , DOI: 10.1039/C8CC07934J

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