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Issue 90, 2018
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Antigen-responsive fluorescent antibody probes generated by selective N-terminal modification of IgGs

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Abstract

Novel fluorescent antibody probes, which show antigen-dependent fluorescence responses, were developed by selective N-terminal fluorescent labeling of IgG monoclonal antibodies using a reductive alkylation. Several kinds of IgG against tag peptides and small molecules were successfully utilized to detect antigens in a rapid and quantitative manner.

Graphical abstract: Antigen-responsive fluorescent antibody probes generated by selective N-terminal modification of IgGs

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Publication details

The article was received on 30 Sep 2018, accepted on 14 Oct 2018 and first published on 25 Oct 2018


Article type: Communication
DOI: 10.1039/C8CC07827K
Citation: Chem. Commun., 2018,54, 12734-12737
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    Antigen-responsive fluorescent antibody probes generated by selective N-terminal modification of IgGs

    K. Fukunaga, T. Watanabe, D. Novitasari, H. Ohashi, R. Abe and T. Hohsaka, Chem. Commun., 2018, 54, 12734
    DOI: 10.1039/C8CC07827K

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