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Induction of apoptosis in MDA-MB-231 breast cancer cells by a PARP1-targeting PROTAC small molecule

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Abstract

Poly (ADP-ribose) polymerase-1 (PARP1) is a major member of the PARP superfamily that is involved in DNA damage signalling and other important cellular processes. Here we report the development of a small molecule targeting PARP1 based on the PROTAC strategy. In the MDA-MB-231 cell line, the representative compound 3 can induce significant PARP1 cleavage and programmed cell death.

Graphical abstract: Induction of apoptosis in MDA-MB-231 breast cancer cells by a PARP1-targeting PROTAC small molecule

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Publication details

The article was received on 30 Sep 2018, accepted on 05 Dec 2018 and first published on 05 Dec 2018


Article type: Communication
DOI: 10.1039/C8CC07813K
Citation: Chem. Commun., 2019, Advance Article
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    Induction of apoptosis in MDA-MB-231 breast cancer cells by a PARP1-targeting PROTAC small molecule

    Q. Zhao, T. Lan, S. Su and Y. Rao, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C8CC07813K

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