Issue 91, 2018
From the journal:

Chemical Communications

Ruthenium-catalyzed C–H oxygenation of quinones by weak O-coordination for potent trypanocidal agents†

Gleiston G. Dias,ab   Torben Rogge,b   Rositha Kuniyil,b   Claus Jacob, ORCID logo c   Rubem F. S. Menna-Barreto,d   Eufrânio N. da Silva Júnior ORCID logo *a  and  Lutz Ackermann ORCID logo *b  

* Corresponding authors

a Institute of Exact Sciences, Department of Chemistry, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil
E-mail: eufranio@ufmg.br

b Institut für Organische und Biomolekulare Chemie, Georg-August-Universität, Göttingen, Tammannstraße 2, 37077 Göttingen, Germany
E-mail: lutz.ackermann@chemie.uni-goettingen.de

c Division of Bioorganic Chemistry, School of Pharmacy, University of Saarland, D-66123 Saarbruecken, Germany

d Oswaldo Cruz Institute, FIOCRUZ, Rio de Janeiro, RJ, Brazil

Abstract

Ruthenium-catalysis enabled the C-5 selective C–H oxygenation of naphthoquinones, and also sets the stage for the site-selective introduction of a hydroxyl group into anthraquinones. A-ring modified naphthoquinoidal compounds represent an important class of bioactive quinones for which the present study encompasses the first C–H oxygenation strategy by weak O-coordination.

Graphical abstract: Ruthenium-catalyzed C–H oxygenation of quinones by weak O-coordination for potent trypanocidal agents

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Article information

DOI
https://doi.org/10.1039/C8CC07572G
Article type
Communication
Submitted
18 Sep 2018
Accepted
16 Oct 2018
First published
16 Oct 2018
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2018,54, 12840-12843

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Ruthenium-catalyzed C–H oxygenation of quinones by weak O-coordination for potent trypanocidal agents

G. G. Dias, T. Rogge, R. Kuniyil, C. Jacob, R. F. S. Menna-Barreto, E. N. da Silva Júnior and L. Ackermann, Chem. Commun., 2018, 54, 12840 DOI: 10.1039/C8CC07572G

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