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Issue 97, 2018
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Fluorescent Wittig reagent as a novel ratiometric probe for the quantification of 5-formyluracil and its application in cell imaging

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Abstract

The chemically selective detection of natural nucleobase modifications has been regarded as the key step in understanding their important roles in epigenetics. Herein, for the first time, we introduce a Wittig reaction into the design of reaction-based fluorescent probes for ratiometrically detecting 5fU, selectively labelling 5fU-modified DNA and imaging intracellular 5fU produced by γ-irradiation.

Graphical abstract: Fluorescent Wittig reagent as a novel ratiometric probe for the quantification of 5-formyluracil and its application in cell imaging

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Publication details

The article was received on 18 Sep 2018, accepted on 05 Nov 2018 and first published on 07 Nov 2018


Article type: Communication
DOI: 10.1039/C8CC07541G
Chem. Commun., 2018,54, 13722-13725

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    Fluorescent Wittig reagent as a novel ratiometric probe for the quantification of 5-formyluracil and its application in cell imaging

    Q. Zhou, K. Li, Y. Liu, L. Li, K. Yu, H. Zhang and X. Yu, Chem. Commun., 2018, 54, 13722
    DOI: 10.1039/C8CC07541G

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