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Issue 90, 2018
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Weak, bidentate chelating group assisted cross-coupling of C(sp3)–H bonds in aliphatic acid derivatives with aryltrifluoroborates

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Abstract

A protocol of Pd(II)-catalyzed, weak bidentate directing group assisted β-C(sp3)–H activation/cross-coupling with organoboron reagents has been achieved, affording arylation of aliphatic acid derivatives that contain α-hydrogen atoms in moderate to good yields. The potential of this method for an asymmetric β-C(sp3)–H arylation via desymmetrization was also presented.

Graphical abstract: Weak, bidentate chelating group assisted cross-coupling of C(sp3)–H bonds in aliphatic acid derivatives with aryltrifluoroborates

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Publication details

The article was received on 14 Sep 2018, accepted on 19 Oct 2018 and first published on 22 Oct 2018


Article type: Communication
DOI: 10.1039/C8CC07481J
Citation: Chem. Commun., 2018,54, 12766-12769
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    Weak, bidentate chelating group assisted cross-coupling of C(sp3)–H bonds in aliphatic acid derivatives with aryltrifluoroborates

    Z. Cai, S. Li, Y. Gao, L. Fu and G. Li, Chem. Commun., 2018, 54, 12766
    DOI: 10.1039/C8CC07481J

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