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Issue 90, 2018
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Polycyclic heteroaromatic ring construction driven by silver/cobalt co-catalyzed desulfonylative and defluorinative fragment-recombination of enol nonaflates with amidines

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Abstract

We present a Ag(I)/Co(II) co-catalyzed tandem fragmentation and recombination reaction commencing from detachable nonaflates and amidines. This catalytic method offers a unique and expeditious access to various fluoroalkylated dihydrobenzo[h]quinazolines and benzo[h]quinazolines in the absence of external fluorine sources through a rationally designed radical desulfonylation, migration, defluorination, and polar condensation relay.

Graphical abstract: Polycyclic heteroaromatic ring construction driven by silver/cobalt co-catalyzed desulfonylative and defluorinative fragment-recombination of enol nonaflates with amidines

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Publication details

The article was received on 12 Sep 2018, accepted on 15 Oct 2018 and first published on 23 Oct 2018


Article type: Communication
DOI: 10.1039/C8CC07409G
Citation: Chem. Commun., 2018,54, 12722-12725
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    Polycyclic heteroaromatic ring construction driven by silver/cobalt co-catalyzed desulfonylative and defluorinative fragment-recombination of enol nonaflates with amidines

    T. Xie, Y. Zhang, L. Liu, Z. Shen, T. Loh and X. Chu, Chem. Commun., 2018, 54, 12722
    DOI: 10.1039/C8CC07409G

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